her2-positive-trials
This list is a quick reference guide to several Phase 3 clinical trials that are currently recruiting in the United States. For assistance with searching for clinical trials, please contact our Helpline at info@bayareacancer.org or (650) 326-6686.
Terms Explained
Vaccine therapy: treatments that train the immune system to recognize cancer cells and kill them.
Trial Name
Trial Type
What is being tested?
Why is this trial significant?
Who might qualify
Who is likely to be excluded?
New Drug
GM-CSF (immune stimulation) +GP2 (a small section of the HER2/neu protein) versus placebo.
This is the most advanced clinical trial for a vaccine-type therapy for breast cancer.
- HER2-positive
- Residual cancer or high risk after chemo+surgery
- HLA-A*02 Positive (immune type)
- Active autoimmune disease
- Prior HER2-targeted vaccine therapy
New Approach
Whether HER2-targeted treatment after surgery (eg. trastuzumab) can be reduced from 12 months to 6.
This is a de-escalation trial exploring whether treatment duration can be safely reduced to minimize adverse impacts.
- HER2-positive
- Early stage
- Complete response to neoadjuvant treatment (prior to surgery)
- Within 14 weeks of surgery
- Did not receive trastuzumab before surgery
- Cancer remaining after surgery
- Heart failure